Leadership

Massimo Imazio, MD

Massimo Imazio is Contract Professor of Physiology (Department of Public Health and Paediatrics, University di Torino) and Cardiology at the Cardiology Specialty School and Internal Medicine Specialty School, University of Torino, Italy. In addition, he is Visiting Professor at the University of Athens and Belgrade, and Consultant Cardiologist at the University Cardiology, AOU Città della Salute e della Scienza, Torino, Italy.

His research focuses on myopericardial diseases and multimodality imaging.

Massimo has been the principal Investigator of eight randomized controlled trials (RCTs), including the first RCTs in pericardial diseases, specifically, COPE (Circulation 2005; 112: 2012; awarded the best study in clinical science at ESC Congress), CORE (Arch Intern Med 2005; 26: 1987), COPPS (Eur Heart J 2010; 31: 2749; Late Breaking Clinical Trial at ESC Congress 2010 and COPPS-AFIB sub study as Late Breaking Clinical Trial at the AHA 2011 Scientific Sessions), CORP (Ann Intern Med 2011; 155: 409; Late Breaking Clinical Trial at ESC Congress 2011), ICAP (NEJM 2013; 369: 1522), CORP 2 (Lancet 2014; 383: 2232-7; Late Breaking Clinical Trial at ACC Scientific Sessions 2014), COPPS 2 (JAMA 2014; 312: 1016; Late Breaking Clinical Trial at ESC Congress 2014), and AIRTRIP (JAMA 2016; 316: 1906; Late Breaking Clinical trial at the 2016 American College of Rheumatology Scientific Sessions). An important contribution of these RCTs was delineation of the role of colchicine and biological agents such as anakinra in the treatment of pericarditis.

He has served as Nucleus member of the ESC Working Group of Myocardial and Pericardial Diseases and Coordinator of the ESC 2015 Guidelines on the management of pericardial diseases. At present he is Fellow of the ESC and Secretary of the ESC Working Group on Myocardial and Pericardial Diseases and Vice-Chair of the Italian study group on this topic.

Dr Imazio is the author of more than 220 papers in peer-reviewed journal (h-index 39), co-author of the chapter on pericardial diseases of the ongoing new edition of Braunwald’s Textbook of Cardiovascular Medicine as well as author in the new ESC Textbook on Cardiovascular Medicine and of UptoDate.

Massimo serves as Editorial Board member of the European Heart Journal and of several journals. In addition to myopericardial diseases (myocarditis, cardiomyopathies, and pericardial diseases), his other areas of interest are infective endocarditis, cardiac magnetic resonance imaging (EACVI accreditation level 3), echocardiography, and clinical cardiology.

Allan Klein, MD

Allan Klein, MD is the Director of the Center for the Diagnosis and Treatment of Pericardial Diseases and a staff cardiologist in the Section of Cardiovascular Imaging, the Robert and Suzanne Tomsich Department of Cardiovascular Medicine, at the Sydell and Arnold Miller Family Heart & Vascular Institute.   He served as Director of CV imaging Research for 24 years. He is board-certified in internal medicine and cardiovascular medicine. He is also the Course Director for Diastology and Contrast Echo & New Technologies Courses—currently his 21st annual course. He is board-certified in internal medicine and cardiovascular medicine. A Canadian by birth, Dr. Klein speaks French and English.

Specialty Interests:

Cardiovascular imaging (echocardiography, cardiac MR and computed tomography); pericardial diseases; amyloid; valvular heart disease; atrial fibrillation; and heart failure with preserved ejection fraction.

Number of Procedures Performed:

Dr. Klein reads well over 2000 echocardiograms per year and performs TEE and intraoperative echocardiogram for the interventional structural program. The pericardial center evaluates over 2400 patients per year of which Dr. Klein sees the majority of patients. He is also heads the pericardiocentesis simulation program which trains the cardiology fellows and performs pericardiocentesis.

Education and Training:

Dr. Klein received his medical degree from McGill University in Montreal, Quebec after completing an undergraduate degree in microbiology and immunology, graduating with honors. While in medical school, he received several scholarships and graduated in the top 10 percent of his class. Dr. Klein completed his clinical training at Mount Sinai Hospital in Toronto and the Royal Victoria Hospital in Montreal.  He completed a Cardiology Residency from the University of Ottawa Heart Institute and a Research Fellowship from the Mayo Clinic in Rochester, Minn. He was appointed to Cleveland Clinic in 1989.

Research, Publications and Speaking:

In addition to his scholarships and academic achievements, Dr. Klein won the E.G.D. Murray Prize in Microbiology and Immunology as an undergraduate and has received multiple American Society of Echocardiography Outcomes Research Awards.

Dr. Klein has been course director and workshop leader at numerous medical specialty conferences focused on clinical trials, imaging modalities and clinical protocols, to name a few. He currently serves as Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western University.  Dr. Klein was a member of the Lerner College of Medicine Admissions Committee.

He has been the principal investigator for multicenter clinical trials in atrial fibrillation (ACUTE I, ACUTE II, and CLOTS); studies in diastolic function (ADEPT); valvular heart disease (Anorexigens and Valve Disease); and catheter ablation and pulmonary vein flow (ROTEA).  He has published key articles in such prestigious journals such as New England Journal of Medicine, Lancet, European Heart Journal, Circulation, and the Journal of the American College of Cardiology.  He chaired the Writing Committee for the document entitled “American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with pericardial disease:  Endorsed by the Society for Cardiovascular Magnetic Resonance and Society of Cardiovascular Computed Tomography.”

Dr. Klein was honored to serve as President of the American Society of Echocardiography (ASE) from June 2016 to June 2017 and now he is a Past-President. He has served on the Board of Directors of the ASE and has been the Chair of the Industry Relations Committee and Chair of the Guidelines and Standards Committee. He is currently chair of the ASE Nominations Committee. Dr. Klein is also on the Writing Committee for the National Board of Echocardiography and served on the Board of Advisors of Cardiovascular Credentialing International. He serves as a peer reviewer for more than 15 professional journals and grades abstracts for the American College of Cardiology, the ASE, the American Heart Association, and the European Society of Cardiology. He is often a Guest Editor for JACC, JACC imaging and Circulation imaging journals.

He has been an invited lecturer at many national and international symposia and conferences, speaking on topics related to his specialty interests. Dr. Klein has authored or co-authored more than 290 peer-reviewed articles in professional journals, co-authored 40 chapters in medical textbooks and published 430 abstracts.  He is a co-editor of 2 books entitled “Diastology: Clinical Approach to Diastolic Heart Failure.” as well as “Clinical Echocardiography Review: A Self-Assessment Tool.” Dr. Klein completed a 2nd edition of the “Clinical Echocardiography Review:  A Self-Assessment Tool.”  He has been the director and co-director of the Annual Diastology and Valve Summit courses for the last 21 years. He is also section editor on pericardial diseases for ACC.org and Current Cardiology reports.

Leisure Time Activities:

Dr. Klein is an avid sportsman and enjoys playing ice hockey, cycling, spinning, hiking and playing many sports. He enjoys reading and traveling around the world.

Professional Highlights:

  • Writing Chair, American Society of Echocardiography Clinical recommendations for Multimodality Cardiovascular Imaging of Patients with Pericardial Disease – 2013
  • Sole Speaker for the ASE Webinar “ASE Clinical Recommendations for Multimodality -2013
  • Notification “In the Spotlight” column of the Cleveland Clinic Professional Staff Update – 2014
  • Invited Visiting Professor at Mount Sinai Hospital for Anandi L. Sharma Visiting Professorship and Simon Dack, MD Memorial Lecture, Heart Failure with Preserved Ejection Fraction with live presentation at heart-talks.org – 2015
  • Section Editor for Pericardial Disease for ACC.org. – 2016
  • Key Note Speaker:  “Constrictive Pericarditis in the 21st Century” at the Portuguese Congress of Cardiology – 2016
  • Elected President of the American Society of Echocardiography – 2017
  • Key note speaker as president of ASE in Thailand, South Korea, Japan, Scotland, India and Australia – 2018
  • Guest Co-Editor for Progress in Cardiovascular Disease 2017;59(4):325-26.
  • Co-Editor of “Clinical Echocardiography Review:  A Self-Assessment Tool.” 2nd Wolters Kluwer – 2017
  • Presented with the ESC Life Achievement Award from the Working Group on Myocardial and Pericardial Diseases in Belgrade, Serbia
  • National PI for the IRB protocol entitled “RHAPSODY: PHASE 3, DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED WITHDRAWAL STUDY WITH OPEN-LABEL EXTENSION, TO ASSESS THE EFFICACY AND SAFETY OF RILONACEPT TREATMENT IN SUBJECTS WITH RECURRENT PERICARDITIS”

Memberships:

  • American Society of Echocardiography
  • American Heart Association
  • American College of Cardiology
  • Royal College of Physicians of Canada
  • Society of Cardiovascular Computed Tomography
  • European Society of Cardiology

Awards and Honors:

  • Fellowships: American College of Cardiology, Royal College of Physicians (Canada), American Society of Echocardiography, American Heart Association, European Society of Cardiology
  • University Scholarship – 1976-1977
  • G.D. Murray Prize in Microbiology and Immunology University Scholar – 1977
  • W. McConnell Award University Scholarship (Phase 1A Medical School) – 1978-1979
  • W. McConnell Award University Scholarship (Phase 1B Medical School) – 1979-1980
  • University Scholarship – 1981
  • Canadian Heart Foundation Research Fellowship – 1986-1988
  • Finalist Canadian Cardiovascular Society Student’s Presentation Award – 1988
  • First Place ASE Outcomes Research Award – 1997-1998
  • Abstract entitled “Assessment of Cardioversion Using TEE Multicenter Study (ACUTE I): Clinical Outcomes at 8 Weeks” was included in the ACC 2000 Meeting Highlights Session as Late Breaking Trial – 2000
  • Mentor for the recipients of the Samuel J. Roessler Memorial Scholarship – 1999-2001
  • Mentor for the recipients of the Am. Society of Echocardiography Fellowship Award – 2000-2001
  • Publication of “Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation” in the New England Journal of Medicine – 2001
  • Abstract entitled “Six-month follow up on patients undergoing a TEE-guided cardioversion from Afib:  the assessment of cardioversion using TEE (ACUTE) trial” was included in the AHA Scientific Sessions 2001 Highlight and ACCEL Online – 2001
  • Publication of “Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation” in the New England Journal of Medicine was sited in Journal Watch Cardiology – 2002
  • Mentor for the nominee of the American Society of Echocardiography Research Finalist Award – 2003
  • Publication of “Pericarditis” in The Lancet – 2004
  • Key Note Speaker:  “New Advances in Echocardiography in Atrial Fibrillation” at the X World Congress of Echo & Cardiovascular Imaging Conference – 2006
  • Publication of “The use of enoxaparin compared with unfractionated heparin for short-term antithrombotic therapy in atrial fibrillation patients undergoing transesophageal echocardiography-guided cardioversion: Assessment of Cardioversion Using Transesophageal Echocardiography (ACUTE) II randomized multicentre study” in the European Heart Journal -2006
  • Study findings of the ACUTE II were highlighted in the Cleveland Clinic Alumni Newsletter – 2007
  • Study findings of the ACUTE II were highlighted in the Cleveland Clinic Annual Report – 2007
  • Grand Rounds presentation at Massachusetts General Hospital on “New Advances in Echocardiography in Afib:  What’s New in the LAA and Pulmonary Veins?” – 2007
  • Co-Editor of “Diastology:  Clinical Approach to Diastolic Heart Failure.”  Saunders, Elsevier, Philadelphia – 2008
  • Mention of the 11th Diastology and New Echo Technologies Summit Featuring Contrast Echo Mini Symposium was cited in the March 2008 Cleveland Clinic OPSA Memo to Staff” 2008
  • Mentor for the winner of the Laennec Young Clinician Award at the American Heart Association Scientific Sessions – 2008
  • New England Journal of Medicine book review for “Diastology: Clinical Approach to Diastolic Heart Failure” in the May 7, 2009, issue – 2009
  • Co-Editor of “Clinical Echocardiography Review:  A Self-Assessment Tool. ” Lippincott, Williams & Wilkins, Philadelphia – 2011
  • CVN (Cardiosource Video Network) Interview Regarding the JACC Imaging Editorial Comment “Annular Velocities in Constrictive Pericarditis – Is it Time to Look Beyond the Annulus” -2011
  • Author Video for JASE regarding “Role of Transesophageal Echocardiography Compared to Computed Tomography in Evaluation of Pulmonary Vein Ablation for Atrial Fibrillation (ROTEA Study)” – 2011
  • Cleveland Clinic “Today’s Headlines” included a story entitled “Heart Failure Takes Bigger Toll on Men” that was Published on UPI.com (coauthor of abstract) – 2012
  • Key Note Speaker: “Is Cardiac Imaging the New Stethoscope?” at the Canadian Cardiovascular Society – 2012
  • Guideline Chair, American Society of Echocardiography Clinical Recommendations for Multimodality Cardiovascular Imaging of Patients with Pericardial Disease – 2013
  • Sole Speaker for the ASE Webinar “ASE Clinical Recommendations for Multimodality Cardiovascular Imaging of Patients with Pericardial Disease: A Guideline in Review” – 2013
  • Notification “In the Spotlight” column of the Cleveland Clinic Professional Staff Update announced the recent appointment of Vice President of the ASE.  After a one-year term, president-elect and then president – 2014
  • Invited Visiting Professor at Mount Sinai Hospital for Anandi L. Sharma Visiting Professorship and Simon Dack, MD Memorial Lecture, Heart Failure with Preserved Ejection Fraction with live presentation at heart-talks.org – 2015
  • 13th Annual Tajik/Seward Lectureship, Cleveland Clinic HVI National Leadership and Diseases Center and IPU Development – 2015
  • Section Editor for Pericardial Disease for ACC.org – 2016
  • Key Note Speaker:  “Constrictive Pericarditis in the 21st Century” at the Portuguese Congress of Cardiology – 2016
  • President of the American Society of Echocardiography – 2016-2017
  • Notification in the Cleveland Clinic “Weekly Scoop:  News from the Chief of Staff” 5 Questions section on providing a one-stop-shop for patients with pericardial disease – 2017
  • Physician’s Weekly article, “Key Concepts in Managing Complicated Pericarditis” – 2017
  • Guest Co-Editor for Progress in Cardiovascular Disease 2017;59(4):325-26
  • Co-Editor of “Clinical Echocardiography Review: A Self-Assessment Tool.” 2nd Wolters Kluwer – 2017

Innovations and Patents:

Dr. Klein has pioneered the use of transesophageal-guided cardioversion in patients with atrial fibrillation in his landmark paper in the New England Journal of Medicine published in 2001 and the European Heart Journal in 2006. He directs one of the largest pericardial center in the world which evaluates complex patients with different pericardial diseases.

Additional Training:

Leading in Health Care Business Program at the CCF